Incidence is increasing across the Western world.
Men are twice as likely as women to develop the disease.
The 2 main histologic types are squamous cell carcinoma and adenocarcinoma. In the US, adenocarcinomas now account for 80% of cases overall.
Low socioeconomic status, smoking, excessive alcohol use, GERD, Barrett esophagus, and obesity are some of the main risk factors.
Tumors are often locally advanced at the time of diagnosis. Accurate staging is important for prognosis and treatment planning.
Superficial intramucosal esophageal cancer is best managed by endoscopic resection and surveillance.
Early stage cancers in surgical candidates are best treated by esophagectomy.
For locally advanced disease, combined modality therapy is considered the current standard. This involves chemotherapy or chemoradiation followed by surgery.
High-risk patients should be treated with combination chemoradiation for best results, but local recurrence rates remain high.
Most esophageal cancers are mucosal lesions that originate in the epithelial cells lining the esophagus.
Cancer Institute of New Jersey System Partnership Leader
Oncology Service Line
MJK is an author of several references cited in this monograph.
Minimally invasive Thoracic Surgery Meridian Health
Meridian Health System
GA declares that he has no competing interests.
Clinical Reader in Surgery
Nuffield Department of Surgery
University of Oxford
PM declares that he has no competing interests.
Assistant Professor of Oncology
Roswell Park Cancer Institute
NIK has received funding for the conduction of clinical trials and associated translational studies from Merck, Pfizer, and Astra-Zeneca. NIK has a grant from the National Comprehensive Cancer Network (from research support by Roche).
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