An intrinsic acute kidney injury caused by ischemic or nephrotoxic injury to renal tubular epithelial cells, which results in tubular dysfunction or detachment from the basement membrane.
A history of hypotension, fluid depletion, or exposure to nephrotoxic agents is usually present.
In otherwise healthy individuals, when the underlying insult is corrected, the patient frequently has a good outcome with complete renal recovery.
There is no specific therapy for acute tubular necrosis apart from supportive care.
Acute kidney injury (AKI) is a common syndrome with a wide variety of etiologies and pathophysiologic processes, characterized by a rapid decrease in renal excretory function over a period of minutes to days. According to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, AKI severity is classified into three stages depending on the serum creatinine level or the extent of oliguria.
Acute tubular necrosis (ATN) is an intrinsic AKI that follows a condition of severe and persistent hypoperfusion or toxic injury of epithelial cells causing detachment of the basement membrane and tubular dysfunction.
History and exam
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Dr Maria Jesus Lloret Cora would like to gratefully acknowledge Dr Roser Torra, the previous contributor to this topic.
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AK has received a fee for speaking about perioperative blood management from Ortho-Biotech and has also received reimbursement from medscape.com for the education webcast of the same presentation.
Chicago Medical School
Rosalind Franklin University
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Department of Family Medicine
University of Texas Health Science Center
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